Detalhe da pesquisa
1.
Massively parallel, computationally guided design of a proenzyme.
Proc Natl Acad Sci U S A
; 119(15): e2116097119, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35377786
2.
Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.
Nucleic Acids Res
; 48(17): 9521-9537, 2020 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32766783
3.
MHCEpitopeEnergy, a Flexible Rosetta-Based Biotherapeutic Deimmunization Platform.
J Chem Inf Model
; 61(5): 2368-2382, 2021 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33900750
4.
Computational Design of a Photocontrolled Cytosine Deaminase.
J Am Chem Soc
; 140(1): 14-17, 2018 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29251923
5.
The role of conformational flexibility in Baeyer-Villiger monooxygenase catalysis and structure.
Biochim Biophys Acta
; 1864(12): 1641-1648, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27570148
6.
A Bis(imidazole)-based cysteine labeling tool for metalloprotein assembly.
J Inorg Biochem
; 244: 112206, 2023 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030124
7.
The substrate-bound crystal structure of a Baeyer-Villiger monooxygenase exhibits a Criegee-like conformation.
J Am Chem Soc
; 134(18): 7788-95, 2012 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-22506764
8.
Novel crystallization conditions for tandem variant R67 DHFR yield a wild-type crystal structure.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 11): 1316-22, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22102224
9.
Ensuring scientific reproducibility in bio-macromolecular modeling via extensive, automated benchmarks.
Nat Commun
; 12(1): 6947, 2021 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34845212
10.
Crystal structures of cyclohexanone monooxygenase reveal complex domain movements and a sliding cofactor.
J Am Chem Soc
; 131(25): 8848-54, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19385644
11.
Structure-Based Design of Dimeric Bisbenzimidazole Inhibitors to an Emergent Trimethoprim-Resistant Type II Dihydrofolate Reductase Guides the Design of Monomeric Analogues.
ACS Omega
; 4(6): 10056-10069, 2019 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31460098
12.
Engineering carboxypeptidase G2 circular permutations for the design of an autoinhibited enzyme.
Protein Eng Des Sel
; 30(4): 321-331, 2017 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28160000
13.
Comprehensive characterization of ligand-induced plasticity changes in a dimeric enzyme.
FEBS J
; 283(16): 3029-38, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27333541
14.
Lactone-bound structures of cyclohexanone monooxygenase provide insight into the stereochemistry of catalysis.
ACS Chem Biol
; 9(12): 2843-51, 2014 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-25265531
15.
Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance.
J Biol Chem
; 284(30): 20079-89, 2009 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-19478082